[Developing the applied course Biotechnological Pharmaceutics under industry-education integration in regional...

The applied courses at regional universities face common industry-education disconnect problems, including course contents lagging behind industrial technological advancements, mismatches between practical training and job competency requirements, and underdeveloped industry-education collaboration mechanisms. To address these problems, this study explores teaching reform practices driven by industry-education integration for Biotechnological Pharmaceutics. Focusing on the drug R&D and production process, we developed an education system featuring five-dimensional integration (concept-mechanism-structure-mode-process) that embeds industrial standards throughout the teaching process. For content restructuring, industrial elements such as engineered cell lines and production protocols were introduced and transformed into design of experiments (DOE)-based tasks, which effectively converted industrial requirements into teaching components. For teaching mode innovation, a "four-in-one" (online resources, offline instruction, laboratory centers, and enterprise platforms) teaching ecosystem was established to guide students through the "design-build-test-learn" engineering cycle via a "virtual-physical combination and university-enterprise alternation" approach. For assessment reform, a "dual-track (emphasizing both process and outcome evaluation), three-stage (before, in, and after class)" quantitative assessment system involving the participation of enterprise mentors was established to align assessment standards with talent demands. After the reform, the proportion of students with excellent and good grades increased significantly, and the interview success rate improved. A number of students were employed by partner enterprises. Moreover, students won multiple awards in provincial-level or higher discipline competitions. The results indicated that the course objective achievement was steadily enhanced. This practice provides an industry-education integration framework for biopharmaceutical courses and serves as an example for regional universities in cultivating talents for developing new quality productive forces.