[Long-term suppression of H+ secretion through a combination of cimetidine and methanthelinbromide (author's transl)]

Inhibition of acid secretion was investigated in 5 patients with Zollinger-Ellison syndrome and 12 patients with duodenal ulcer after administration of 200 mg cimetidine alone and combined with 50 mg methanthelinebromide. A preinvestigation of 5 patients had not shown any significant decrease of acid secretion after 50 mg methanthelinebromide alone. Compared with a single dose of 200 mg cimetidine, combined drugs' use (200 mg cimetidine and 50 mg methanthelinebromide) led to significant increase of inhibition of secretion both as regards degree and duration. In 6 patients with duodenal ulcer basal secretion of more than 2.0 mmol H+/h 200 mg cimetidine led to inhibition of secretion by 91.4% over 120 min compared to 96.4% over 225 min after combined administration. Similar results were obtained in 6 patients with a basal secretion of less than 2.0 mmol H+/h.