Related Experiment Video
Updated: Aug 5, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Exact Decomposition of Adversarial Dual-Objective Value Functions, with Applications to Optimal Drug Dosing
Dylan Hirsch1, William Sharpless1, Sylvia Herbert1
1Department of Mechanical and Aerospace Engineering, University of California at San Diego, 9500 Gilman Drive MC 0411, La Jolla, CA 92093.
Abstract:
Hamilton-Jacobi Reachability (HJR) is a central framework in safe control theory. While HJR has traditionally focused on a few fundamental tasks, there is increasing interest in scaling to more complex objectives. Recent works have studied the exact decomposition of the value functions for two fundamental dual-objective tasks in the adversary-free setting. However, not all value function decompositions in HJR remain valid with an adversary. In this work, we develop theoretical approaches to certify that for these two composite value functions, the proposed decompositions still hold with an adversary. Finally, we show how these results can solve issues that arise when applying HJR to optimal drug regimen design.
Related Concept Videos
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Pharmacodynamic Models: Additive and Proportional Drug Effect Model
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Dosage Regimens: Partial Pharmacokinetic Parameters