Nonlinear dose-response effects of exercise interventions on post-stroke depression: a systematic review and
Meiyao Liu1, Ziqi Gao1, Yaxin Wang1
1Graduate School, Harbin Sport University, Harbin, China.
Frontiers in Public Health
|July 29, 2026
Summary
Exercise interventions modestly improve post-stroke depression (PSD) symptoms. Moderate-dose exercise, around 801 MET-min/week, shows the greatest benefit for individuals with PSD.
Area of Science:
- Neurology
- Psychiatry
- Rehabilitation Medicine
Background:
- Post-stroke depression (PSD) is a common complication affecting patient recovery and quality of life.
- Understanding the impact of exercise interventions is crucial for managing PSD.
Purpose of the Study:
- To systematically evaluate exercise effects on post-stroke depression (PSD).
- To determine the dose-response relationship between physical activity and depressive symptoms in PSD patients.
Main Methods:
- A comprehensive literature search was conducted across major databases (PubMed, Web of Science, Embase, Scopus, Cochrane Library).
- Meta-analysis and restricted cubic spline models were used to analyze data from 31 randomized controlled trials involving 2,247 participants.
- Dose-response and subgroup analyses were performed to identify optimal exercise parameters.
Main Results:
- Exercise intervention showed a modest improvement in depressive symptoms for PSD patients (SMD = -0.15).
- A non-linear dose-response relationship was observed, with peak benefits around 801 MET-min/week.
- Resistance training, 1-2 sessions/week, sessions ≤30 min, and 9-12 weeks duration yielded better outcomes.
Conclusions:
- Moderate-dose exercise (approx. 801 MET-min/week) offers modest improvements for post-stroke depressive symptoms.
- Findings support optimizing exercise dosage and developing individualized prescription strategies for PSD management.
