Related Experiment Video
Updated: Aug 5, 2026
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
The trends of retinoblastoma research in the past decade
Yu-Hang Yang1, Wen-Da Zhou1, Han-Qing Zhao1
1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Aim:
To conduct a bibliometric analysis of retinoblastoma (RB) research to delineate global research trends, identify key research contributors, and highlight emerging research directions in this field.
Methods:
Publications from 2015 to 2024 were collected from the Web of Science Core Collection. Data on publication volume, citations, H-indexes, and collaborative networks were analyzed using CiteSpace.
Results:
In total, 1719 publications were included. Annual publication outputs on RB research exhibited an overall upward trend. The United States dominated global RB research with 500 publications (29.09%), 8978 citations and an H-index of 43, followed by China (468 articles, 27.23%) and India. Switzerland and Spain yielded the highest average citation per article, at 29.00 and 27.72, respectively. Institution-wise, Thomas Jefferson University (76 publications) and Memorial Sloan Kettering Cancer Center (70 publications) ranked top in publication quantity. Indian Journal of Ophthalmology was the most prolific journal with 52 relevant articles, while Shields CL was the leading author contributing 67 papers in this domain. Cited-reference analysis identified the article entitled "Global Retinoblastoma Presentation and Analysis by National Income Level" in JAMA Ophthalmology as the most frequently cited work with the strongest citation burst. Journals covering molecular biology and genetics constitute the fundamental academic basis for contemporary RB investigations. Keyword analysis demonstrated that "cancer", "management", "expression", and "chemotherapy" were the most recurrent research hotspots.
Conclusion:
This study performed the first decade-long CiteSpace-based bibliometric analysis of RB. Substantial disparities in publication productivity and clinical practice exist across nations and institutions. Low- and middle-income countries (LMICs) remain burdened by diagnostic and therapeutic limitations for RB, highlighting the necessity of strengthened international collaboration. Future research priorities encompass overcoming chemotherapy resistance, optimizing intra-arterial chemotherapy (IAC) regimens, and translating molecular discoveries into accessible therapies via global partnerships.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...