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Updated: Aug 5, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Arterial Stiffness and Cognitive Impairment in Patients With Arterial Hypertension: CAVI and haSTART Index

T A Safronova1, S E Mukhanova1, T S Vargina1

  • 1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, mma.ru.

International Journal of Vascular Medicine
|July 29, 2026
PubMed

Insights

Arterial stiffness, measured by CAVI and haSTART, is linked to cognitive impairment in hypertension patients. This study confirms the association between these stiffness measures and cognitive decline, highlighting potential cardiovascular disease risks.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Arterial stiffness is a key risk factor for cardiovascular diseases (CVDs), including cognitive impairment (CogI) and vascular dementia.
  • Hypertension (HTN) is a significant contributor to arterial stiffness and subsequent cognitive decline.

Purpose of the Study:

  • To investigate the relationship between the cardio-ankle vascular index (CAVI) and the heart-ankle Stiffness of Arteries (haSTART) index in patients with arterial hypertension (HTN).
  • To explore the association of CAVI and haSTART with cognitive impairment (CI) in patients diagnosed with HTN.

Main Methods:

  • Arterial stiffness was assessed using CAVI and the haSTART index.
  • Cognitive status was evaluated using the Montreal Cognitive Assessment (MoCA).
  • A cohort of 128 patients (96 with HTN, 32 controls) aged 35-79 years was studied.

Main Results:

  • A strong correlation was found between CAVI and haSTART (r = 0.977, p < 0.001).
  • Significant negative correlations were observed between MoCA scores and CAVI (r = -0.502, p = 0.001) and haSTART (r = -0.512, p = 0.001).

Conclusions:

  • Arterial stiffness, as measured by CAVI and haSTART, is associated with cognitive impairment in patients with hypertension.
  • This study establishes a novel correlation between the haSTART index and cognitive function, reinforcing the link between arterial stiffness and CI.
Abstract

Keywords:
CAVIarterial stiffnesscognitive impairmenthaSTART indexhypertension

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