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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Life-Space Mobility in Heart Failure With Preserved Ejection Fraction
Dylan Marshall1, Omar Zainul2, Musarrat Nahid3
1Department of Medicine, Columbia University Irving Medical Center, New York, New York.
Journal of Cardiac Failure - Intersections
|July 29, 2026
Summary
Life-space mobility, measuring movement range, is linked to poorer quality of life and increased hospitalization risk in heart failure with preserved ejection fraction (HFpEF) patients. This mobility measure can serve as a key health and prognostic indicator.
Area of Science:
- Cardiology
- Geriatrics
- Public Health
Background:
- Life-space mobility, an individual's movement range, is an understudied metric relevant to multiple health domains.
- Heart failure with preserved ejection fraction (HFpEF) is a prevalent condition where life-space mobility's association with adverse outcomes remains unclear.
- Assessing life-space mobility in ambulatory HFpEF patients is crucial for understanding their health status and prognosis.
Purpose of the Study:
- To investigate the association between life-space mobility and adverse clinical outcomes in patients with HFpEF.
- To determine if life-space mobility correlates with quality of life in HFpEF patients.
- To evaluate the prognostic value of the Life-Space Assessment (LSA) and a simplified LSA in this population.
Main Methods:
- 175 consecutive HFpEF patients were analyzed using the Life-Space Assessment (LSA) and a simplified LSA to quantify mobility.
- Quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire-12 and EuroQol 5-Dimension 5-level.
- A 12-month composite of all-cause mortality and hospitalization was the primary outcome, analyzed with Cox proportional-hazard models.
Main Results:
- Patients with low life-space mobility reported significantly worse quality of life.
- Low life-space mobility, assessed by both LSA and simplified LSA, was independently associated with a 2.4-fold increased risk of 12-month all-cause hospitalization.
- The findings were consistent across both LSA measures after full adjustment for covariates.
Conclusions:
- Life-space mobility in HFpEF patients reflects health deficits and quality of life.
- Reduced life-space mobility is a significant independent predictor of adverse clinical outcomes, including hospitalization.
- Both the LSA and simplified LSA are comparable and valuable tools for assessing health and prognosis in HFpEF.
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