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Updated: Aug 5, 2026
09:41
Performing and Processing FNA of Anterior Fat Pad for Amyloid
Published on: October 30, 2010
Renal Amyloidosis: An Approach to Uniform Biopsy Reporting
Mohita Ray1, Biswajit Mishra2, Nibedita Sahoo1
1Department of Pathology, IMS & SUM Hospital, Siksha 'O' Anusandhan (Deemed University), Bhubaneswar, IND.
Cureus
|July 29, 2026
Summary
Renal amyloidosis prognosis improves with standardized histopathology reporting. The Renal Amyloid Prognostic Score (RAPS) and histologic grading correlate with clinical severity, aiding in patient management.
Area of Science:
- Nephrology
- Pathology
Background:
- Renal amyloidosis leads to progressive kidney failure.
- Standardized biopsy reporting enhances prognostic accuracy and interinstitutional comparisons.
Purpose of the Study:
- To apply the Sen and Sarsik histopathologic classification.
- To calculate the Renal Amyloid Prognostic Score (RAPS).
- To correlate histologic grade with clinical severity in renal amyloidosis.
Main Methods:
- Retrospective analysis of 18 biopsy-proven renal amyloidosis cases.
- Assignment of Glomerular Amyloid Pattern (GAP) classes, RAPS, and histologic grade.
- Correlation of histologic findings with clinical data (proteinuria, creatinine) using statistical analyses.
Main Results:
- Prevalence of renal amyloidosis was 1.78%, predominantly primary amyloid light chain (AL) type.
- Glomerular deposition was universal, with GAP class IV and Grade 3 associated with higher proteinuria and creatinine.
- RAPS showed positive correlation with proteinuria and serum creatinine.
Conclusions:
- RAPS and histologic grading offer consistent evaluation of renal amyloid burden.
- These parameters correlate with clinical severity, informing prognosis.
- Prompt biopsies and standardized reporting are crucial for guiding treatment.
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03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...