Association Between GRACE Score and Right Ventricular Function Assessed by 3D Echocardiography in Patients With Acute...

Area of Science:

• Cardiology
• Echocardiography
• Acute Coronary Syndromes

Background:

• The GRACE score predicts in-hospital mortality in ST-elevation myocardial infarction (STEMI) patients.
• Right ventricular (RV) dysfunction is a significant predictor of adverse outcomes in STEMI.
• The relationship between GRACE score and RV function needs further exploration.

Purpose of the Study:

• To investigate the association between the GRACE score and RV function in patients with acute inferior STEMI undergoing primary percutaneous coronary intervention (PCI).
• To assess RV ejection fraction, volumes, and stroke volume using three-dimensional echocardiography.

Main Methods:

• A cross-sectional pilot study including 40 patients with acute inferior STEMI post-primary PCI.
• Three-dimensional echocardiography was performed 24-48 hours after PCI.
• GRACE score and RV parameters were analyzed using correlation and regression.

Main Results:

• A significant negative correlation was found between the GRACE score and RV end-diastolic volume (r = -0.314, p = 0.048).
• The GRACE score also negatively correlated with RV stroke volume (r = -0.340, p = 0.032).
• Heart rate showed associations with both left and right ventricular function.

Conclusions:

• An exploratory association exists between the GRACE score and RV function in STEMI patients undergoing primary PCI.
• These hypothesis-generating findings require validation in larger prospective studies.