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Association Between Dietary Anthocyanidin Intake and Thyroid Autoimmunity: A Cross-Sectional Study From NHANES
Mingkuan Chen1, Yirong Yuan2, Yuan Zhao1
1Department of Thyroid and Breast Surgery Pu'er People's Hospital Pu'er P. R. China.
Health Science Reports
|July 29, 2026
Summary
Higher dietary intake of anthocyanidins is linked to an increased risk of thyroid autoimmunity (TAI). This study suggests a potential dose-response relationship between anthocyanidin consumption and TAI incidence.
Area of Science:
- Nutrition science
- Immunology
- Epidemiology
Background:
- Anthocyanidins are known for their immunomodulatory effects.
- Population-based studies on anthocyanidins and thyroid autoimmunity (TAI) are lacking.
Purpose of the Study:
- To investigate the association between dietary anthocyanidin intake and TAI.
- To examine the dose-response relationship between anthocyanidin intake and TAI incidence.
Main Methods:
- Utilized data from the Flavonoid and Anthocyanidin Database (FNDDS) and NHANES (2007-2010).
- Employed multivariable logistic regression and restricted cubic spline models.
- Analyzed data from 5,487 participants, adjusting for covariates.
Main Results:
- TAI patients had significantly higher anthocyanidin intake than controls.
- Increased anthocyanidin intake correlated with a higher risk of TAI.
- A linear dose-response relationship was observed between anthocyanidin intake and TAI risk.
Conclusions:
- This study identified an association between dietary anthocyanidin intake and TAI.
- Further research, including prospective studies and clinical trials, is needed.
- Elucidating the underlying mechanisms is crucial for validating these findings.
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