Programmable nanomedicine via bioorthogonal molecular engineering
Sunwoo Im1, Seyoung Koo2,3, Jong Seung Kim4,5
1Department of Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Korea.
Nano Convergence
|July 29, 2026
Summary
Bioorthogonal chemistry enables advanced programmable nanomedicines. This approach allows precise control over drug delivery and therapeutic functions, improving treatment selectivity and efficacy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Organic Chemistry
Background:
- Traditional nanomedicines have limitations in precise control over drug delivery and activation.
- Bioorthogonal chemistry offers novel strategies to overcome these limitations.
Purpose of the Study:
- To review recent advancements in bioorthogonal chemistry for programmable nanomedicines.
- To highlight applications in surface functionalization, drug release, and nanoparticle assembly.
Main Methods:
- Post-synthetic modification of nanoparticle surfaces using bioorthogonal reactions.
- Spatiotemporal control over payload activation and release mechanisms.
- Engineering nanoparticle aggregation and cell conjugation for targeted delivery.
Main Results:
- Demonstrated enhanced selectivity in nanomedicine activation.
- Enabled complex functions difficult to achieve with conventional formulations.
- Facilitated precise control over drug release kinetics and targeting.
Conclusions:
- Bioorthogonal engineering is a powerful tool for developing next-generation programmable nanomedicines.
- Future directions include addressing challenges in multiscale engineering and clinical translation.
