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Updated: Aug 5, 2026
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Sleeve Gastrectomy Effect on Structural and Functional Myocardium Characteristics and Trpc3, Trpc6, Tgfb1, and Atp2a2
V I Pan1, O V Kornyushin1, T A Lelyavina2
1Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Abstract:
A positive effect of sleeve gastrectomy on the structural and functional characteristics of the left ventricular myocardium in rats with normal body weight and post-infarction CHF was demonstrated. Sleeve gastrectomy attenuated the upregulated myocardial expression of the Trpc6 and Tgfb1 genes involved in the pathogenesis of myocardial infarction. These findings attest to a reduction of the negative effects of post-infarction cardiac remodeling.
