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Updated: Aug 5, 2026
09:10
A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
SynFlow: an interactive online genome structural variant viewer
Marilyne Summo1,2,3, Gaëtan Droc1,2,3, Mathieu Rouard3,4
1UMR AGAP Institut, Univ Montpellier, CIRAD, INRAE, Institut Agro, Montpellier, France.
Bioinformatics (Oxford, England)
|July 29, 2026
Summary
SynFlow offers a dynamic web-based tool for interactive exploration of structural variations (SVs) in large genomic datasets. This application enhances comparative genomics by enabling real-time filtering and visualization of complex genomic events.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- Structural variations (SVs) are critical for genome evolution and phenotypic diversity.
- Advancements in genome assembly necessitate improved methods for SV detection and interpretation.
- Existing visualization tools for SVs are often static, limiting interactive exploration of large datasets.
Purpose of the Study:
- To develop an interactive web-based application for visualizing structural variations.
- To address the limitations of static plots in comparative genomics research.
- To provide a dynamic platform for exploring and filtering SVs in real time.
Main Methods:
- Introduction of SynFlow, a lightweight, web-based interactive application.
- Utilizing SyRI for structural variation detection.
- Developing dynamic, shareable visualizations with real-time filtering and reordering capabilities.
Main Results:
- SynFlow successfully reproduces complex static synteny plots from literature.
- The application transforms static plots into dynamic visualizations supporting deep exploration of SVs.
- SynFlow offers multiple access points: precomputed datasets, user-uploaded data, and on-the-fly analysis.
Conclusions:
- SynFlow enhances the interactive exploration of structural variations in genomics.
- The tool facilitates real-time analysis and visualization of complex genomic events.
- SynFlow provides a valuable resource for comparative genomics research.
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