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Updated: Aug 5, 2026
08:07
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Alterations in Cellular Immunity in Patients With Endometriosis: Systematic Review and Meta-Analysis
Leila Adamyan1,2, Laura Pivazyan2, Kristina Kurbatova1
1Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine, Moscow, Russia.
Summary
Endometriosis pathogenesis involves altered cellular immunity, particularly in T lymphocytes, monocytes, macrophages, and natural killer cells. Further research is needed to fully understand these immune system changes in endometriosis patients.
Area of Science:
- Gynecology
- Immunology
- Cellular Biology
Background:
- Endometriosis pathogenesis remains poorly understood, presenting a significant challenge in women's health.
- Investigating cellular immunity alterations offers potential insights into endometriosis development.
Purpose of the Study:
- To synthesize existing research on cellular immunity markers in endometriosis.
- To compare immune cell concentrations and cytokine levels between endometriosis patients and controls.
Main Methods:
- A qualitative synthesis of 24 studies identified through a comprehensive database search.
- Comparative analysis of Interleukin-4 (IL-4), Interleukin-6 (IL-6), HLA-DR+-macrophages, HLA-ABC+-macrophages, and Natural Killer (NK) cells.
Main Results:
- Elevated IL-6 concentration in peritoneal fluid of endometriosis patients (p = 0.009).
- No significant differences observed in IL-4, HLA-DR+-macrophages, HLA-ABC+-macrophages, or NK-cell levels between groups.
- Trends suggest alterations in immune cell levels within ectopic and eutopic endometrium.
Conclusions:
- Endometriosis is associated with altered immune cell signaling pathways, including T lymphocytes, monocytes, macrophages, and NK cells.
- Specific immune markers like IL-6 may play a role in endometriosis pathogenesis.
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