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MITD1 restricts HIV-1 release by targeting ESCRT-III proteins

Jim Zoladek1, Marion Cannac2, Claire Lacouture1

  • 1Institut de Recherche en Infectiologie de Montpellier (IRIM), Montpellier University, Centre National de la Recherche Scientifique (CNRS) UMR 9004, INSERM, Montpellier, France.

Cell Reports
|July 29, 2026
PubMed
Summary

MITD1, an interferon-stimulated gene, inhibits HIV-1 release by disrupting the ESCRT-III complex assembly. This discovery reveals a new innate immunity mechanism controlling viral egress.

Keywords:
CP: microbiologyCP: molecular biologyESCRT-IIIHIV-1 egressMITD1innate antiviral immunityinterferon-stimulated genesmicrogliarestriction factorsviral budding

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