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Paresthesia After Suzetrigine: A Second Report and Case Comparison
1Western Reserve Hospital-Center for Pain Medicine, Cuyahoga Falls, Ohio, USA.
Journal of Pain & Palliative Care Pharmacotherapy
|July 29, 2026
Summary
Suzetrigine, a novel non-opioid analgesic, may cause paresthesia in patients with acute pain. This report details a second case of paresthesia following suzetrigine administration for refractory postoperative pain.
Area of Science:
- Pharmacology
- Neurology
- Pain Management
Background:
- Suzetrigine is a new non-opioid analgesic approved for moderate to severe acute pain.
- Common side effects include pruritis and muscle spasm.
- A previous case report documented paresthesia after suzetrigine administration.
Purpose of the Study:
- To report a second instance of paresthesia in a patient receiving suzetrigine.
- To discuss potential neurological side effects of suzetrigine.
Main Methods:
- Case report of a patient treated for refractory postoperative pain.
- Clinical observation of adverse events following suzetrigine administration.
Main Results:
- The patient experienced paresthesia, a neurological symptom, shortly after receiving suzetrigine.
- Symptoms were similar to a previously reported case.
Conclusions:
- Paresthesia may be an adverse effect of suzetrigine.
- Further investigation into the neurological side effect profile of suzetrigine is warranted.
