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Updated: Aug 5, 2026
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Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
Published on: October 28, 2022
Renal impairment after burn-associated shock
Julia Kleinhapl1,2, Lucineia Gainski Danielski1, Kristine Knappskog3
1Department of Surgery, Division of Surgical Sciences, University of Texas Medical Branch, Galveston, TX.
Shock (Augusta, Ga.)
|July 29, 2026
Summary
Burn-associated shock significantly increases mortality and the risk of acute kidney injury (AKI) and renal replacement therapy (RRT). Enhanced renal surveillance is crucial for burn patients experiencing shock.
Area of Science:
- Nephrology
- Trauma Surgery
- Critical Care Medicine
Background:
- Burn injuries often lead to shock, critical illness, and multi-organ dysfunction, potentially causing renal injury.
- While acute kidney complications are recognized, long-term renal outcomes post-burn are not well understood.
Purpose of the Study:
- To investigate the long-term renal outcomes and mortality associated with shock in adult burn patients.
- To compare outcomes between burn patients with and without shock, and between those with and without acute kidney injury (AKI) after shock.
Main Methods:
- A global network database (TriNetX) was queried for adult burn patients who developed shock within 7 days of injury.
- Propensity score matching was used to compare patients with and without shock, controlling for various clinical factors.
- Outcomes assessed included acute kidney injury (AKI), chronic kidney disease (CKD), renal replacement therapy (RRT), and mortality.
Main Results:
- Burn patients who developed shock had significantly higher 3-month and 1-year mortality rates compared to those without shock.
- Shock was associated with a significantly increased risk of developing AKI and requiring RRT in the short and long term.
- Within the shock cohort, AKI was further associated with increased mortality.
Conclusions:
- Burn-associated shock is linked to elevated risks of AKI, RRT, and mortality.
- These findings underscore the need for vigilant renal monitoring and kidney-protective interventions in burn patients experiencing shock.
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