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KRAS Mutations Reprogram RNA m6A Modifications to Drive CD73-Dependent Immune Evasion in Colorectal Cancer

Seungjae Shin1, Seung-Pyo Hong1, Seoho Lee1

  • 1Seoul National University College of Medicine Seoul Korea (South), Republic of.

Cancer Research
|July 29, 2026
PubMed
Summary

KRAS mutations in colorectal cancer (CRC) promote immune evasion by altering RNA methylation (m6A). Targeting METTL3 restores antitumor immunity and improves immunotherapy response in KRAS-mutant CRC.

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