Characterizing obsessive-compulsive features in Duchenne muscular dystrophy: a DSM-5 approach

Area of Science:

• Neurology
• Psychiatry
• Genetics

Background:

• Obsessive-Compulsive Disorder (OCD) traits are increasingly observed in Duchenne Muscular Dystrophy (DMD).
• Limited standardized diagnostic data exists for OCD in DMD patients.
• This study addresses the need for systematic evaluation of OCD traits in DMD.

Purpose of the Study:

• To systematically examine Obsessive-Compulsive Disorder traits in pediatric and young adult patients with Duchenne Muscular Dystrophy.
• To assess the prevalence and impact of OCD traits on functioning in DMD.
• To explore correlations between genetic factors, cognitive performance, and OCD traits in DMD.

Main Methods:

• A single-center, cross-sectional observational study.
• Enrolled 77 Duchenne Muscular Dystrophy patients.
• Utilized standardized psychometric instruments for cognitive and OCD assessment.

Main Results:

• Obsessive-Compulsive Disorder traits were identified in 68.8% of DMD patients.
• OCD traits significantly correlated with reduced general functioning.
• Associations found between DMD gene mutation site, cognitive performance, and OCD traits.

Conclusions:

• A high prevalence of OCD traits exists in Duchenne Muscular Dystrophy patients.
• Nuanced clinical evaluation and individualized interventions are necessary.
• A holistic approach is vital for managing OCD traits in the DMD population.