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Updated: Aug 5, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Psoriasis
Lihi Eder1, Lourdes Perez-Chada2, Wilson Liao3
1Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada; Department of Medicine, Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Lancet (London, England)
|July 29, 2026
Summary
Psoriasis is a chronic immune skin disease impacting millions globally. Advances in understanding its immune pathways have led to targeted therapies for better disease control.
Area of Science:
- Immunodermatology
- Rheumatology
- Genetics
Background:
- Psoriasis is a prevalent, chronic, immune-mediated skin condition affecting over 40 million people worldwide.
- It is part of the psoriatic disease spectrum, involving inflammatory skin and musculoskeletal issues driven by shared mechanisms.
- Psoriasis presents diverse clinical phenotypes and is linked to significant psychosocial burden and comorbidities like mental health and cardio-metabolic diseases.
Purpose of the Study:
- To summarize the current understanding of psoriasis pathogenesis.
- To highlight the role of genetic and environmental factors.
- To discuss recent therapeutic advancements targeting key inflammatory pathways.
Main Methods:
- Review of current scientific literature on psoriasis.
- Analysis of genetic, immunological, and clinical data.
- Evaluation of therapeutic strategies and their efficacy.
Main Results:
- Psoriasis involves complex immune dysregulation, with genetic factors like HLA-C*06:02 and environmental triggers playing key roles.
- The IL-23-IL-17 inflammatory axis is central to psoriasis pathogenesis.
- Targeted therapies modulating cytokine signaling offer significant disease control.
Conclusions:
- Psoriasis is a complex immune disorder with significant systemic implications.
- Understanding the immunogenetic basis has enabled the development of effective targeted therapies.
- Biologic and small-molecule drugs provide improved management for cutaneous and musculoskeletal symptoms.
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