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Updated: Aug 5, 2026

Methods to Enable Spatial Transcriptomics of Bone Tissues
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Proteome-wide Multi-omics Profiling of Osteosarcoma Transcription Factor Networks

Nguyen Xuan Thang1, Emily Martinsen1, Mohamed Abdelhalim1

  • 1Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Journal of Molecular Biology
|July 29, 2026
PubMed
Summary

This study identifies key transcription factors (TFs) driving aggressive osteosarcoma (OS) behavior. RUNX2 and MYBL2 are linked to increased invasiveness, while ETV5, TBX15, and USF1 may play roles in less aggressive forms.

Keywords:
catTFREsmulti-omicsosteosarcomaregulatory networkstranscription factors

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