Related Experiment Video

Updated: Aug 5, 2026

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

On the Chopping Block: Overview of DICER1 Mutations in Endocrine and Neuroendocrine Neoplasms

Carl Christofer Juhlin1

  • 1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Clinics in Laboratory Medicine
|July 29, 2026
PubMed

Insights

Mutations in the DICER1 gene disrupt micro-RNA maturation, contributing to tumor formation. This review focuses on DICER1 inactivation

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • DICER1 gene mutations lead to abnormal micro-RNA (miRNA) processing.
  • This dysregulation impacts posttranscriptional gene expression, promoting tumor development.
  • Germline DICER1 mutations define DICER1 syndrome, increasing risks for various cancers.

Purpose of the Study:

  • To review the critical role of DICER1 inactivation in the development of endocrine tumors.
  • To highlight the significance of DICER1 in both inherited and sporadic tumor formation.

Main Methods:

  • Literature review of studies on DICER1 mutations and associated tumors.
  • Analysis of the impact of aberrant miRNA maturation on gene expression.
  • Focus on endocrine tumor development linked to DICER1 inactivation.

Main Results:

  • DICER1 inactivation is a key factor in various solid tumors.
  • Both germline and somatic DICER1 mutations contribute to neoplastic conditions.
  • Endocrine glands are among the tissues affected by DICER1-related tumorigenesis.

Conclusions:

  • DICER1 plays a crucial role in preventing tumor formation.
  • Understanding DICER1's function is vital for diagnosing and treating DICER1 syndrome and related endocrine tumors.
  • Targeting pathways affected by DICER1 inactivation may offer therapeutic strategies.
Keywords:
DICER1Endocrine tumorMutationNeuroendocrine neoplasiaReview

More Related Videos

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...