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Significant Association of Cyclin Dependent Kinase Inhibitor 1B Genotypes With Lung Cancer Risk Among Smokers
Te-Chun Shen1,2,3, Ya-Chen Yang4, Chia-Hsiang Li1,5
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Anticancer Research
|July 29, 2026
Summary
The cyclin dependent kinase inhibitor 1B (CDKN1B) rs34330 gene variant may increase lung cancer risk in smokers. This genetic factor interacts with smoking behavior, highlighting a gene-environment interaction in lung carcinogenesis.
Area of Science:
- Genetics
- Oncology
- Environmental Health
Background:
- Lung cancer is a leading cause of cancer mortality globally, with smoking as a primary risk factor.
- Genetic susceptibility, particularly involving cell-cycle regulatory genes like CDKN1B, requires further investigation.
- Identifying genetic biomarkers can improve understanding of lung cancer development.
Purpose of the Study:
- To investigate the association between CDKN1B polymorphisms (rs34330 and rs2066827) and lung cancer risk in a Taiwanese cohort.
- To explore the potential interaction between these CDKN1B polymorphisms and smoking status in relation to lung cancer risk.
Main Methods:
- Genotyping of CDKN1B rs34330 and rs2066827 in 358 lung cancer patients and 716 controls using PCR-RFLP.
- Statistical analysis including chi-square tests and odds ratio calculations.
- Stratified analyses based on smoking status to assess gene-environment interactions.
Main Results:
- No significant association was found between CDKN1B rs34330 or rs2066827 genotypes and overall lung cancer risk.
- However, carriers of the rs34330 TT genotype showed a significantly elevated risk of lung cancer among smokers (OR=1.59, p=0.0372).
- This increased risk in smokers with the rs34330 TT genotype persisted after adjusting for age and sex.
Conclusions:
- CDKN1B polymorphisms alone are not independently linked to lung cancer susceptibility.
- The rs34330 polymorphism may interact with cigarette smoking, increasing lung cancer risk in individuals who smoke.
- These findings suggest a gene-environment interaction in smoking-related lung carcinogenesis, requiring validation in diverse populations.
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