Related Experiment Video
Updated: Aug 5, 2026
08:11
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
Analysis for IL-22/ IL-22BP Axis and Cell Adhesion Molecules in Advanced Colorectal Cancer
Naohiro Yoshida1, Masayuki Takamatsu2, Kenta Takaki2
1Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan yoshida_naohiro@kurume-u.ac.jp.
Anticancer Research
|July 29, 2026
Summary
Interleukin-22 binding protein (IL-22BP) expression is a significant prognostic biomarker in advanced colorectal cancer (CRC). Low IL-22BP levels indicate poor survival, suggesting its potential as a therapeutic target to improve patient outcomes.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- The mucosal barrier's integrity, influenced by cytokines and cell adhesion molecules, is vital in colorectal cancer (CRC) progression.
- Interleukin-22 (IL-22) is key to intestinal homeostasis, while its antagonist, IL-22 binding protein (IL-22BP), acts as a soluble decoy receptor.
Purpose of the Study:
- To investigate the clinical significance of IL-22BP.
- To explore the association between IL-22BP and cell adhesion molecules in advanced CRC patients.
Main Methods:
- Retrospective analysis of 178 stage II and III CRC patients undergoing curative resection.
- Immunohistochemical evaluation of IL-22, IL-22BP, claudin-1, and β-catenin protein expression.
- Correlation analysis with clinicopathological features and survival outcomes.
Main Results:
- High IL-22BP expression correlated significantly with claudin-1 expression (p=0.043).
- Patients with low IL-22BP expression had shorter recurrence-free survival (RFS) (p=0.015) and overall survival (OS) (p=0.037).
- Low IL-22BP was an independent predictor of poor RFS (HR=2.265) and OS (HR=2.502). IL-22 and β-catenin showed no prognostic association.
Conclusions:
- IL-22BP expression is linked to claudin-1 and serves as an independent prognostic biomarker in advanced CRC.
- The IL-22/IL-22BP axis may influence tight junction integrity, potentially inhibiting tumor progression.
- IL-22BP emerges as a potential therapeutic target for CRC treatment.
Related Concept Videos
01:20Cell Adhesion Molecules - Types and Functions
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...
CAM Families
The Integrin family of proteins is primarily involved in a...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
01:35Cancer Cell Migration through Invadopodia
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
01:31Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
01:25Selectins
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...