Related Experiment Video
Updated: Aug 5, 2026
09:34
Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
Published on: November 27, 2017
Transamniotic stem cell therapy (TRASCET)
Hannah Ananda Bougleux Gomes1, Dario O Fauza1
1Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States.
Seminars in Pediatric Surgery
|July 29, 2026
Summary
Transamniotic stem cell therapy (TRASCET) offers a minimally invasive prenatal stem cell delivery method. This approach leverages natural maternal-fetal transport for potential therapeutic applications in fetal development.
Area of Science:
- Regenerative Medicine
- Prenatal Medicine
- Stem Cell Biology
Background:
- Transamniotic stem cell therapy (TRASCET) is a novel, minimally invasive method for prenatal stem cell delivery.
- It utilizes the natural transport of donor cells from amniotic fluid across the amnio-placental interface to the fetus.
Purpose of the Study:
- To review the biological basis, applications, and operational principles of TRASCET.
- To highlight the therapeutic potential of TRASCET in preclinical models.
Main Methods:
- The review summarizes existing experimental data on TRASCET.
- It focuses on the mechanism of donor cell transport and distribution within the fetus.
Main Results:
- TRASCET has demonstrated broad therapeutic potential in various animal models.
- Donor cells can reach fetal circulation and target sites like bone marrow.
Conclusions:
- TRASCET capitalizes on natural fetal development processes for stem cell replenishment.
- While promising, clinical translation is still pending, but may be imminent.
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