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Thrombotic Microangiopathy After Kidney Transplantation Associated With Rifampicin: A Case Report

Agatha Prado de Lima1, Diogo Buarque Cordeiro Cabral1, Alexandre de Holanda Cavalcanti Pinto1

  • 1Department of Nephrology and Kidney Transplantation at the Real Hospital Português de Beneficência em Pernambuco, Recife, Pernambuco State, Brazil.

Transplantation Proceedings
|July 29, 2026
PubMed

Insights

Thrombotic microangiopathy (TMA) is a serious risk after kidney transplantation (KT). Rifampicin (RIF) can trigger TMA in susceptible patients, necessitating prompt drug withdrawal for better outcomes.

Area of Science:

  • Nephrology
  • Pharmacology
  • Transplantation Medicine

Background:

  • Thrombotic microangiopathy (TMA) is a severe complication post-kidney transplantation (KT).
  • TMA is linked to high rates of morbidity, mortality, and graft loss.
  • Rifampicin (RIF) is a rarely reported but potential trigger for TMA in susceptible individuals.

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