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Updated: Aug 5, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
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Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

The Methicillin-Resistant S pseudintermedius Crisis: Are We Out of Options to Treat the Most Common Canine Pathogen?

Douglas H Pluta1, Jessica M Gilbertie1

  • 1Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA 24061, USA.

The Veterinary Clinics of North America. Small Animal Practice
|July 29, 2026
PubMed

Insights

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) causes difficult-to-treat canine skin infections. New therapies are emerging to combat MRSP, reducing the need for systemic antibiotics.

Area of Science:

  • Veterinary Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Staphylococcus pseudintermedius is a primary cause of canine pyoderma.
  • Methicillin-resistant S pseudintermedius (MRSP) presents significant clinical challenges due to multidrug resistance and biofilm formation.
  • Recurrent infections are exacerbated by treatment failures and repeated antimicrobial use.

Purpose of the Study:

  • To review the emergence, epidemiology, and resistance mechanisms of MRSP.
  • To discuss the limitations of current treatment strategies for MRSP infections.
  • To explore novel therapeutic approaches for managing MRSP infections.

Main Methods:

  • Literature review of MRSP emergence, resistance, and treatment.
  • Analysis of current therapeutic options and their limitations.
  • Identification and discussion of emerging treatment strategies.

Main Results:

  • MRSP infections are increasingly difficult to manage due to multidrug resistance and biofilm persistence.
  • Current antimicrobial treatments have limitations in effectively eradicating MRSP.
  • Several novel therapeutic strategies show promise in combating MRSP.

Conclusions:

  • Effective management of MRSP requires understanding its resistance and epidemiology.
  • Emerging therapies offer alternatives to systemic antimicrobials for MRSP infections.
  • Future strategies focus on adjunct treatments to reduce antimicrobial reliance.
Keywords:
Antimicrobial resistanceAntimicrobial stewardshipBiofilmEmerging therapeuticsMRSPMultidrug resistanceStaphylococcus pseudintermedius

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