Related Experiment Video
Updated: Aug 5, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
Targeting Yes-Associated Protein (YAP)/Transcriptional Coactivators with PDZ-Binding Motif (TAZ)-Transcriptional
Ramesh Kumar1, Zebin Hong2, Sakshibeedu R Bharath2
1Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Republic of Singapore hong_wanjin@a-star.edu.sg ramesh_kumar@a-star.edu.sg.
Abstract:
The evolutionarily conserved Hippo signaling pathway is crucial for regulating organ size, tissue homeostasis, and regeneration. Mammalian Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) and its interaction with transcriptional enhanced associate domain 1-4 (TEAD1-4) are vital for transcriptional outputs linked to cell proliferation and apoptosis. Dysregulation of Hippo signaling is associated with various aspects of cancer biology. The convergence of the Hippo signaling network with diverse oncogenic pathways places it at the center of tumorigenic adaptation, maintenance of stemness, and the development of drug resistance. Modulating YAP/TAZ-TEAD signaling offers broad therapeutic potential, from cancer treatment to regenerative medicine. Several small-molecule TEAD inhibitors are at various stages of clinical development, with increasing efforts focused on monotherapy and combination therapies targeting YAP/TAZ hyperactivation caused by standard-of-care (SOC) drugs (best available disease-specific treatments used in clinics), particularly targeted therapies.
More Related Videos
09:55All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
Published on: December 20, 2021
10:32Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
Published on: December 19, 2019
Related Concept Videos
Master Transcription Regulators
Co-activators and Co-repressors
Co-activators and Co-repressors
Eukaryotic Transcription Activators
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
TGF - β Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...