Related Experiment Video
Updated: Aug 5, 2026
Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Relationship between MSpO2 and depressive symptoms in older patients with obstructive sleep apnea: a cross-sectional
Ying-Hui Gao1, Xin Xue2, Dong Rui3
1PKU-UPenn Sleep Center, Peking University International Hospital, Beijing, China.
Objective:
This study explored risk factors associated with depressive symptoms in older patients with obstructive sleep apnea (OSA) and assessed correlations of mean pulse oxygen saturation (MSpO2) with depressive symptoms.
Methods:
In total, 1,085 older patients diagnosed with OSA via polysomnography (PSG) were included. Based on scores from the 12-item Geriatric Depression Scale (GDS-12), participants were classified into two subgroups to identify depressive symptom-related risk factors. Logistic regression analysis, restricted cubic splines, and subgroup analyses were performed to evaluate correlations of MSpO2 with depressive symptoms.
Results:
Depressive symptoms were observed in 139 patients (12.8% of the sample). Logistic regression analysis indicated that age (per 1-year increase, odds ratio [OR] = 1.11, 95% confidence interval [CI]: 1.08-1.14; P < 0.001), smoking (OR = 1.66, 95% CI: 1.02-2.69; P = 0.041), MSpO₂ (per 1% increase, OR = 0.90, 95% CI: 0.85-0.94; P < 0.001), diabetes mellitus (OR = 1.61, 95% CI: 1.03-2.51; P = 0.038), and renal dysfunction (OR = 2.26, 95% CI: 1.10-4.66; P = 0.027) were significantly associated with depressive symptoms. Additionally, sleep parameters including AHI, ODI, and LSpO₂ were independently associated with depressive symptoms. Restricted cubic splines suggested a linear correlation between MSpO₂ and depressive symptoms (nonlinear P = 0.38). Compared with patients in the highest category (MSpO₂ ≥ 95.0%), those in the lowest category (MSpO₂ ≤ 91.7%) showed increased depressive symptom risk (OR = 2.25, 95% CI: 1.34-3.78, P = 0.002). Subgroup analyses confirmed this linear relationship.
Conclusion:
A linear correlation exists between MSpO2 and depressive symptoms in older patients with OSA. Additionally, age, smoking, diabetes mellitus, and renal dysfunction are strongly associated with depressive symptoms in this population.
