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In a nutshell review of hereditary antithrombin deficiency in pregnancy
Oluwatosin Afolabi1, Samuel Ruder2, Maria T DeSancho2
1Department of Internal Medicine, Weill Cornell Medicine, New York City, New York, USA.
British Journal of Haematology
|July 30, 2026
Summary
Hereditary antithrombin deficiency significantly elevates the risk of blood clots in pregnant individuals. Specialized anticoagulation and care strategies are crucial for improving outcomes for both mother and baby.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Genetics
Background:
- Hereditary antithrombin deficiency is a genetic condition increasing thrombophilia risk.
- Pregnancy and postpartum periods present heightened venous thromboembolism risks for affected individuals.
Purpose of the Study:
- To summarize the risks associated with hereditary antithrombin deficiency during pregnancy.
- To outline optimal management strategies for pregnant individuals with this condition.
Main Methods:
- Review of existing literature on hereditary antithrombin deficiency and pregnancy.
- Analysis of individualized anticoagulation and multidisciplinary care approaches.
Main Results:
- Markedly increased maternal venous thromboembolism risk identified.
- Successful outcomes achieved with tailored treatment plans.
Conclusions:
- Individualized anticoagulation, including low-molecular-weight heparin and antithrombin concentrate replacement, is effective.
- Multidisciplinary care is essential for optimizing maternal and fetal well-being in hereditary antithrombin deficiency.
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