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Published on: May 2, 2025
Advanced Nanomaterials for Chronic Wounds: M.O.I.S.T. Concept-Driven Design Strategy
Yingying Li1, Chen Hu2, Keyi Fang1
1School of Stomatology, Hainan Medical University, Haikou, Hainan Province, P. R. China.
Advanced Healthcare Materials
|July 30, 2026
Summary
This review introduces the M.O.I.S.T. framework for designing nanomaterials to improve chronic wound healing. It details how nanomaterials can optimize moisture, oxygen, infection control, and tissue management for better patient outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Chronic wound management presents significant challenges due to complex causes, infection risks, and patient variability.
- Conventional therapies have limitations, and nanomaterials offer tunable properties for advanced wound healing solutions.
- Current research on rational nanomaterial design for wound healing lacks a systematic framework.
Purpose of the Study:
- To review recent advances in nanomaterial design for chronic wound healing.
- To introduce and elaborate on the M.O.I.S.T. (moisture balance, oxygen balance, infection control, supporting strategies, tissue management) framework for guiding nanomaterial development.
- To establish a correlation between the M.O.I.S.T. framework and nanomaterial design for personalized nanotherapies.
Main Methods:
- Systematic review of recent literature on nanomaterial applications in chronic wound healing.
- Categorization of nanomaterial strategies based on the five core dimensions of the M.O.I.S.T. framework.
- Discussion of specific nanomaterial functionalities including structural innovation, oxygen regulation, multi-mechanistic infection control, pathological microenvironment support, and tissue management.
Main Results:
- Nanomaterials can be precisely tailored for optimal moisture balance through structural innovation.
- Oxygen-releasing/consuming nanosystems can regulate the oxygen balance in wound environments.
- Multi-mechanistic infection control strategies (PTT/PDT/SDT, nanozymes) and advanced nanostructures are effective.
- Targeted support for pathological microenvironments and enhanced tissue debridement, proliferation, and remodeling are achievable with tailored nanomaterials.
- Nanomaterials play a role in modulating wound microbiota to restore immune-microbial homeostasis.
Conclusions:
- The M.O.I.S.T. framework provides a systematic approach to designing nanomaterials for chronic wound healing.
- This framework-guided design offers theoretical and practical guidance for developing personalized nanotherapies.
- Further research and addressing challenges are crucial for the clinical translation of M.O.I.S.T.-guided nanomaterials.
