Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer
Jia Xuan Tan1, Hua Run Yu2, Yong Gu2
1Key Laboratory of Tropical Disease Control of Sun Yat-Sen University, Ministry of Education, The Institute of Immunology of Zhong Shan Medical School, Sun Yat-Sen University, Guangzhou, China.
Abstract:
T lymphocytes, essential components of the adaptive immune system, orchestrate pathogen-specific responses and long-term immunological memory through heterogeneous subsets with distinct functional properties and spatial distributions. This comprehensive review delineates the origin, distribution, and functional specialization of long-lasting T cell subsets-naive T cells (Tn), stem cell-like memory T cells (Tscm), central memory T cells (Tcm), effector memory T cells (Tem), and tissue-resident memory T cells (Trm)-across physiological and pathological contexts, with a particular focus on aging and non-small cell lung cancer (NSCLC). We further dissect the complex intertwined mechanisms underlying immunosenescence and NSCLC pathogenesis. Elucidating how aging remodels T cell maintenance, tissue tropism and metabolic adaptation provides a conceptual framework for developing targeted therapeutic interventions against NSCLC.
More Related Videos
11:02Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
Published on: January 20, 2017
09:15Identification of Rare Antigen-Specific T Cells from Mouse Lungs with Peptide:Major Histocompatibility Complex Tetramers
Published on: July 19, 2024
Related Concept Videos
lncRNA - Long Non-coding RNAs
Replicative Cell Senescence
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
