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Inflammation and the Heart: The Role of Traditional Factors

Mostafa Cheraghi1, Arash Amin2, Solmaz Jabarzare3

  • 1Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran, lums.ac.ir.

Cardiology Research and Practice
|July 30, 2026
PubMed

Insights

Many cardiac patients lack typical risk factors, highlighting the need for new predictors. This study explores inflammation

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Approximately 50% of patients with heart disease lack traditional cardiac risk factors.
  • Emerging evidence implicates systemic and localized inflammation in atherosclerosis and cardiovascular conditions.
  • Elevated levels of inflammatory biomarkers, such as C-reactive protein (CRP), are linked to increased cardiovascular disease risk.

Purpose of the Study:

  • To identify additional factors contributing to heart disease etiology beyond conventional risk factors.
  • To analyze the role of inflammation in the development of atherosclerosis, endothelial dysfunction, and plaque rupture.
  • To explore potential strategies for mitigating inflammation associated with cardiovascular disease.

Main Methods:

  • Review of existing studies on the etiology of coronary artery disease.
  • Analysis of the relationship between inflammatory markers and cardiovascular conditions.
  • Examination of mechanisms underlying atherosclerosis, endothelial dysfunction, and plaque rupture.

Main Results:

  • Inflammation plays a critical role in the pathogenesis of cardiovascular disease.
  • Specific inflammatory biomarkers are associated with increased risk of atherosclerosis and cardiac events.
  • Understanding these inflammatory pathways can aid in predicting high-risk cardiovascular patients.

Conclusions:

  • Inflammation is a key contributing factor to heart disease, independent of traditional risk factors.
  • Identifying and targeting inflammatory pathways offers a promising approach for cardiovascular disease prevention and management.
  • Further research into novel biomarkers and anti-inflammatory strategies is warranted.

Keywords:
atherosclerosisheartinflammationinterleukins

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