Case Report: Multi-drug-resistant pneumonia and chronic enteropathy in a Bernadoodle with selective IgA deficiency

This case is the first to describe a selective immunoglobulin A deficiency (sIgAD) in a Bernadoodle with recurrent multi-drug-resistant (MDR) pneumonia and a chronic enteropathy. The patient experienced chronic coughing and regurgitation from puppyhood, and advanced imaging and endoscopic procedures documented MDR Bordetella bronchisceptica (Bb) and Mycoplasma infections. Serum immunology testing documented sIgAD. Clinical signs have been well-managed with long-term prophylactic antibiotics, anti-inflammatory steroids, probiotics, and hydrolyzed protein diet. Low serum IgA levels have not been previously documented in the Bernese Mountain dog nor designer cross breeds, such as the Bernadoodle.