Assessment of genetically modified soybean DAS-44406 × FG72 (dossier GMFF-2025-34192)

Area of Science:

• Agricultural Biotechnology
• Genetics and Molecular Biology
• Food Safety

Background:

• Genetically modified soybean DAS-44406-6 × FG72 was developed by combining two single events, DAS-44406-6 and FG72, through conventional crossing.
• This stacked soybean event expresses four proteins (AAD-12, 2mEPSPS, PAT, and HPPD W336) conferring tolerance to multiple herbicides, including 2,4-D, glyphosate, glufosinate, and HPPD inhibitors.

Purpose of the Study:

• To assess the food, feed, and environmental safety of the genetically modified soybean DAS-44406-6 × FG72.
• To evaluate if the combination of single soybean events and newly expressed proteins raises any safety or nutritional concerns.

Main Methods:

• Review of previous assessments of single soybean events (DAS-44406-6 and FG72).
• Molecular characterization, comparative analysis (agronomic, phenotypic, compositional), toxicological, allergenicity, and nutritional assessments.
• Evaluation of environmental safety in case of accidental release or spillage.

Main Results:

• The GMO Panel found no safety concerns with the previously assessed single soybean events.
• Molecular, compositional, toxicological, and nutritional assessments indicated no food, feed, or nutritional concerns for the stacked soybean.
• Environmental safety assessment concluded no concerns for processed products or accidental seed spillage.

Conclusions:

• Genetically modified soybean DAS-44406-6 × FG72 is as safe as its non-GM comparator and reference varieties for food, feed, and the environment.
• No post-market monitoring for food and feed is deemed necessary.
• Post-market environmental monitoring plans align with intended uses, with no environmental safety concerns identified.