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Microglia as Double-Edged Players in Ischemic Stroke

Shiyuan Lin1, Zejing Lin1, Ying Chen1

  • 1Department of Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, 350001 Fuzhou, Fujian, China.

Journal of Integrative Neuroscience
|July 30, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
ischemic strokemetabolic reprogrammingmicroglianeuroinflammation

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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