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Updated: Aug 5, 2026
12:19
Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
RNA-Binding Protein RBMS3 Inhibits Cervical Cancer Progression by Enhancing HSPA6 mRNA Stability
Huaping Huang1,2, Ping Li3, Lixia Zhu2
1The Reproductive Medicine Center, The Second Affiliated Hospital of Soochow University, 215004 Suzhou, Jiangsu, China.
Frontiers in Bioscience (Landmark Edition)
|July 30, 2026
Summary
RNA-binding motif single-stranded interacting protein 3 (RBMS3) suppresses cervical cancer (CC) by stabilizing heat shock protein family A member 6 (HSPA6) mRNA. This RBMS3-HSPA6 interaction offers a potential therapeutic target for CC.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Cervical cancer (CC) is a common women's cancer.
- The tumor-suppressive role of RNA-binding motif single-stranded interacting protein 3 (RBMS3) in CC is not well understood.
Purpose of the Study:
- To investigate the function and regulatory mechanisms of RBMS3 in cervical cancer.
- To identify potential therapeutic targets for CC treatment.
Main Methods:
- Assessed RBMS3 and heat shock protein family A member 6 (HSPA6) expression in clinical CC tissues.
- Conducted gain- and loss-of-function assays, transcriptome sequencing, and xenograft studies in CC cell lines and mouse models.
Main Results:
- RBMS3 expression was significantly lower in CC tissues and correlated with reduced patient survival.
- RBMS3 overexpression inhibited CC cell proliferation, migration, invasion, and tumor growth.
- RBMS3 stabilizes HSPA6 mRNA, and HSPA6 knockdown reversed RBMS3's tumor-suppressive effects.
Conclusions:
- RBMS3 inhibits CC progression by enhancing HSPA6 mRNA stability.
- The RBMS3-HSPA6 pathway presents a potential prognostic biomarker and therapeutic target for cervical cancer.
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