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Published on: January 21, 2012

RNA-Binding Protein RBMS3 Inhibits Cervical Cancer Progression by Enhancing HSPA6 mRNA Stability

Huaping Huang1,2, Ping Li3, Lixia Zhu2

  • 1The Reproductive Medicine Center, The Second Affiliated Hospital of Soochow University, 215004 Suzhou, Jiangsu, China.

Frontiers in Bioscience (Landmark Edition)
|July 30, 2026
PubMed
Abstract

Insights

RNA-binding motif single-stranded interacting protein 3 (RBMS3) suppresses cervical cancer (CC) by stabilizing heat shock protein family A member 6 (HSPA6) mRNA. This RBMS3-HSPA6 interaction offers a potential therapeutic target for CC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cervical cancer (CC) is a common women's cancer.
  • The tumor-suppressive role of RNA-binding motif single-stranded interacting protein 3 (RBMS3) in CC is not well understood.

Purpose of the Study:

  • To investigate the function and regulatory mechanisms of RBMS3 in cervical cancer.
  • To identify potential therapeutic targets for CC treatment.

Main Methods:

  • Assessed RBMS3 and heat shock protein family A member 6 (HSPA6) expression in clinical CC tissues.
  • Conducted gain- and loss-of-function assays, transcriptome sequencing, and xenograft studies in CC cell lines and mouse models.

Main Results:

  • RBMS3 expression was significantly lower in CC tissues and correlated with reduced patient survival.
  • RBMS3 overexpression inhibited CC cell proliferation, migration, invasion, and tumor growth.
  • RBMS3 stabilizes HSPA6 mRNA, and HSPA6 knockdown reversed RBMS3's tumor-suppressive effects.

Conclusions:

  • RBMS3 inhibits CC progression by enhancing HSPA6 mRNA stability.
  • The RBMS3-HSPA6 pathway presents a potential prognostic biomarker and therapeutic target for cervical cancer.
Keywords:
RNA-binding proteincervical cancerheat shock proteinpost-transcriptional regulationtumor suppressor

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