Nanomaterial Platforms for Endometriosis: A Systematic Review

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Reproductive Medicine

Background:

• Endometriosis (EM) is a prevalent, estrogen-dependent inflammatory condition impacting women's health.
• Current treatments for EM face limitations including systemic side effects and high recurrence rates.

Purpose of the Study:

• To systematically review nanotechnology-based drug delivery platforms for endometriosis.
• To compare hydrogels, extracellular vesicles (EVs), and inorganic nanoparticles for EM treatment.

Main Methods:

• Systematic review of nanomaterial platforms for EM.
• Analysis of physicochemical properties, therapeutic rationale, and preclinical data.
• Comparison of platforms' efficacy in addressing EM pathology.

Main Results:

• Hydrogels, EVs, and inorganic nanoparticles show promise for targeted EM drug delivery.
• Each platform presents unique strengths and limitations in addressing inflammation, fibrosis, and angiogenesis.
• Preclinical data suggest potential for reduced systemic toxicity compared to conventional therapies.

Conclusions:

• Nanotechnology-based drug delivery is a promising strategy for improving endometriosis treatment.
• Further research is needed to optimize nanocarrier design and clinical translation for EM.
• This review provides a framework for comparing nanocarrier strategies for endometriosis.