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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Obstetric and Neonatal Factors Associated with Postpartum Depressive Symptoms: A Retrospective Multicenter EPDS-Based
Mehmet Nuri Duran1, Abdurrahman Sengi2, İlke Açar Duran3
1Department of Obstetrics and Gynecology, Ezine State Hospital, Çanakkale, Turkey. drmnduran@gmail.com.
Advances in Therapy
|July 30, 2026
Summary
Postpartum depressive symptoms affected 26% of women. History of abortion and preeclampsia were significantly associated with these symptoms in mothers without prior psychiatric history.
Area of Science:
- Obstetrics and Gynecology
- Psychiatry
- Public Health
Background:
- Postpartum depressive symptoms are a significant concern affecting maternal mental health.
- The Edinburgh Postnatal Depression Scale (EPDS) is a key tool for screening these symptoms.
- Identifying associated risk factors is crucial for targeted interventions.
Purpose of the Study:
- To evaluate postpartum depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS).
- To identify demographic, obstetric, and neonatal factors linked to EPDS positivity.
- To focus on women without a prior psychiatric history.
Main Methods:
- A retrospective, multicentre study of 763 women aged 20-35 years.
- Data collected on demographics, obstetric history (including abortion, stillbirth, preeclampsia), and neonatal outcomes (NICU admission).
- Logistic regression with Bonferroni adjustment was used to analyze EPDS scores (≥13 indicating positivity).
Main Results:
- 26.0% of women screened positive for postpartum depressive symptoms (EPDS ≥13).
- History of abortion and preeclampsia were independently associated with EPDS positivity after statistical adjustments.
- Factors like working status and NICU admission showed non-significant associations post-correction.
Conclusions:
- Postpartum depressive symptoms impact approximately one in four women.
- Preeclampsia and a history of abortion are significant risk factors for postpartum depressive symptoms.
- Targeted psychological screening is recommended for high-risk pregnancies and those with neonatal complications.
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