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Updated: Aug 5, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
Maartina J P Oosterom-Eijmael1,2,3, Abraham H Hulst1,3,4, Nelson P Monteiro de Oliveira5
1Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
JAMA
|July 30, 2026
Summary
Preoperative dapagliflozin significantly reduced acute kidney injury (AKI) in patients undergoing cardiac surgery. This study demonstrates a novel preventive strategy for AKI, a common postoperative complication.
Area of Science:
- Nephrology
- Cardiology
- Clinical Trials
Background:
- Acute kidney injury (AKI) affects 2%-50% of patients post-cardiac surgery.
- Effective preventive medications for postoperative AKI remain unidentified.
Purpose of the Study:
- To evaluate the efficacy of dapagliflozin in reducing AKI incidence after elective cardiac surgery.
- To compare dapagliflozin initiated preoperatively versus placebo.
Main Methods:
- A multicenter, double-blind, placebo-controlled randomized clinical trial.
- Adults undergoing elective cardiac surgery received dapagliflozin (10 mg daily) or placebo, starting 1 day before surgery for 4 doses.
- Primary outcome: AKI incidence within 7 days post-surgery.
Main Results:
- Dapagliflozin reduced AKI incidence from 52% to 28% (Relative Risk, 0.54; P < .001).
- No significant difference in atrial fibrillation or reoperation rates between groups.
- Trial NCT05590143.
Conclusions:
- Initiating dapagliflozin preoperatively is effective in preventing AKI in cardiac surgery patients.
- This represents a potential new therapeutic approach for AKI prevention in this high-risk population.
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