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Updated: Aug 5, 2026
06:31
Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
[Extrapulmonary lymphangioleiomyomatosis with retroperitoneal lymph node involvement]
A A Borzova1, V A Smolyannikova1, A V Filatov1
1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Arkhiv Patologii
|July 30, 2026
Summary
Lymphangioleiomyomatosis (LAM) is a rare smooth muscle proliferation disease. Pelvic lymph node LAM presents subtly, often incidentally found during gynecologic cancer surgeries.
Area of Science:
- Oncology
- Pulmonology
- Pathology
Background:
- Lymphangioleiomyomatosis (LAM) is a rare disease affecting women of reproductive age, characterized by smooth muscle cell proliferation.
- While most commonly pulmonary, extrapulmonary LAM occurs in lymph nodes (mediastinum, abdomen, retroperitoneum).
- Pelvic lymph node LAM symptoms are subtle, often compression-related or incidentally discovered.
Purpose of the Study:
- To review literature on lymph node LAM.
- To present a case of pelvic lymph node LAM in a patient with metastatic endometrial cancer.
Main Methods:
- Literature review.
- Case report.
Main Results:
- Extrapulmonary LAM, including in pelvic lymph nodes, is a recognized entity.
- Pelvic lymph node LAM can mimic other conditions or be found incidentally during gynecologic procedures.
- The presented case highlights LAM in a patient with advanced endometrial cancer.
Conclusions:
- Lymph node LAM is an important consideration in extrapulmonary manifestations of the disease.
- Incidental diagnosis during gynecologic oncology surgery is common for pelvic lymph node LAM.
- Further research is needed to understand the full spectrum and management of extrapulmonary LAM.