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Aptasensors for lung cancer detection
Lanlan He1, Xinping Zhao1, Xinyi Zhang1
1Institute of Cytology and Genetics, MOE Key Lab of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China; Institute for Future Sciences, University of South China, Changsha, 410000, China.
Talanta
|July 30, 2026
Summary
Novel aptasensors offer a promising solution for early lung cancer detection. These sensitive, non-invasive biosensors utilize aptamers for accurate diagnosis, improving patient survival rates.
Area of Science:
- Biomedical Engineering
- Molecular Diagnostics
- Oncology
Background:
- Lung cancer is a leading cause of cancer death globally, with late diagnosis limiting treatment efficacy.
- Current diagnostic methods like imaging and biopsy have limitations, necessitating more sensitive and non-invasive approaches.
- Aptamers, as specific DNA/RNA recognition molecules, present an opportunity for advanced biosensor development.
Purpose of the Study:
- To review the application of aptamers in lung cancer detection.
- To summarize advancements in aptamer-based sensors (aptasensors) for lung cancer diagnosis.
- To critically evaluate the performance, limitations, and translational challenges of current aptasensor platforms.
Main Methods:
- Literature review focusing on aptamer-based biosensors for lung cancer.
- Comparative analysis of five mainstream aptasensor platforms.
- Evaluation of analytical performance, clinical utility, and obstacles to clinical translation.
Main Results:
- Aptasensors demonstrate high sensitivity, non-invasiveness, and rapid detection capabilities for lung cancer.
- Aptamers offer advantages such as low cost, high stability, and ease of modification for biosensor design.
- Comparison reveals varying analytical performances and significant clinical and translational hurdles across different aptasensor platforms.
Conclusions:
- Aptasensors hold significant potential for improving early lung cancer diagnosis.
- Further research is needed to overcome clinical limitations and facilitate the translation of aptasensor technology.
- Development of accurate and efficient aptasensor-based diagnostic techniques is crucial for enhancing lung cancer patient outcomes.
