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Updated: Aug 5, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Next-generation colon-targeted oral delivery for immune modulation in inflammatory bowel diseases
Shang-Wen Lin1, Letong Wang1, Po-Han Chao1
1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
None:
Localized therapy via oral drug delivery remains particularly challenging for inflammatory bowel diseases (IBD) due to the distinct anatomical and pathophysiological features of the colonic region in the gastrointestinal (GI) tract. Despite extensive exploration of diverse formulation strategies for IBD management, clinical translation has remained limited, resulting in a paucity of effective oral treatment options. This review integrates current mechanistic insights into colon-specific immune pathophysiology with emerging trends in oral formulation development. All of which underscores the urgent need for advanced formulation strategies that integrate multiple targets for IBD treatment.
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