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Health-Related Quality of Life and Utility Values in Chinese Patients with Non-Small-Cell Lung Cancer: A Multicenter
Luying Wang1, Xin Guan1, Yue Wang1
1School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, China.
Summary
This study provides crucial health-related quality of life utility values for Chinese patients with non-small-cell lung cancer (NSCLC). These findings support economic evaluations and cost-effectiveness analyses in China.
Area of Science:
- Health Economics
- Oncology
- Quality of Life Research
Background:
- Limited evidence exists for robust economic evaluations in China.
- Growing interest in cost-effectiveness analysis necessitates reliable utility data.
Purpose of the Study:
- To assess health-related quality of life (HRQoL) in Chinese patients with non-small-cell lung cancer (NSCLC).
- To generate utility values for informing economic evaluations and cost-effectiveness analyses.
Main Methods:
- A multicenter cross-sectional survey was conducted in 20 hospitals across China (October 2022 - March 2024).
- HRQoL data were collected using EQ-5D-5L, SF-6D, and QLQ-C30 instruments.
- Ordinary least squares regression analyzed determinants of utility.
Main Results:
- 947 NSCLC patients were included; most had advanced stage (III/IV) cancer.
- Mean EQ-5D-5L utility score was 0.801 (SD:0.273), varying by cancer stage and treatment line.
- SF-6D and QLQ-C30 scores were lower than EQ-5D-5L, with pain/discomfort and physical functioning being key impaired dimensions.
Conclusions:
- The study provides essential EQ-5D-5L, SF-6D, and QLQ-C30 utility values for Chinese NSCLC patients.
- Instrument-dependent differences in utility values were observed.
- Findings are crucial for informing cost-effectiveness analyses in NSCLC care in China.