Related Experiment Video
Updated: Aug 5, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Inadvertent Placement of Pacing Leads Into the Left Ventricle
Anmol Multani1, Sravani Modumudi1, Ryan Tang1
1Department of Cardiology, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
This study investigates recurrent strokes in a patient with atrial fibrillation despite anticoagulation. Further evaluation is needed to identify the cardioembolic source and underlying cause.
Area of Science:
- Neurology
- Cardiology
- Radiology
Background:
- A 65-year-old male with a history of paroxysmal atrial fibrillation and sinus node dysfunction presented with acute neurological deficits.
- The patient had a dual-chamber pacemaker implanted 4 years prior and was on apixaban for stroke prevention.
- Despite anticoagulation, the patient experienced recurrent strokes.
Purpose of the Study:
- To investigate the cause of recurrent strokes in a patient with known atrial fibrillation and pacemaker.
- To determine the underlying etiology of multifocal cerebral infarcts despite anticoagulation therapy.
Main Methods:
- Clinical presentation and history review.
- Non-contrast computed tomography (CT) of the head.
- Magnetic resonance imaging (MRI) of the brain.
Main Results:
- MRI revealed multiple small acute and chronic infarcts in the cerebellum, parietal, and frontal lobes.
- The distribution of infarcts suggested a multifocal embolic source.
- Initial CT head scan was unremarkable for acute changes.
Conclusions:
- A cardioembolic source was suspected due to the multifocal infarct distribution.
- Further evaluation is necessary to identify the specific etiology of recurrent strokes.
Related Concept Videos
Cardiac Catheterization III: Left Heart Catheterization
Electrocardiogram Fundamentals
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin to...
Cardiac Catheterization II: Right Heart Catheterization
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias IV: Characteristics of Bradyarrhythmias

