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Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes
Cooper T Bowring1, Matthew J Watt1
1Department of Physiology, Faculty of Medicine, Dentistry and Health Science, University of Melbourne, Parkville, Victoria 3010, Australia.
Trends in Endocrinology and Metabolism: TEM
|July 30, 2026
Summary
Researchers developed a new mouse model for identifying secreted proteins. This proximity labeling tool captures cell-specific secretomes in plasma and tissue, aiding in understanding physiological functions and diseases.
Area of Science:
- Proteomics
- Molecular Biology
- Biochemistry
Background:
- Secreted proteins play crucial roles in physiological processes and disease development.
- Current methods for identifying secreted proteins in vivo are limited.
- Understanding the cell-specific secretome is vital for biological and medical research.
Purpose of the Study:
- To introduce a novel genetically encoded proximity labeling mouse model.
- To enable the capture of cell-specific secretomes in vivo.
- To facilitate the study of secreted proteins in response to physiological stimuli.
Main Methods:
- Development of a genetically encoded proximity labeling mouse model.
- Application of the model to capture cell-specific secretomes.
- Analysis of secreted proteins in plasma and tissue samples.
Main Results:
- Successful establishment of a proximity labeling mouse model for secretome analysis.
- Demonstration of the model's capability to capture cell-specific secreted proteins.
- Identification of secreted proteins under various physiological conditions.
Conclusions:
- The developed mouse model offers a powerful tool for in vivo secretome analysis.
- This technology advances the study of secreted proteins in health and disease.
- Enables deeper insights into the roles of secreted proteins in physiological regulation and pathology.
