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Updated: Aug 5, 2026

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Lysosomes join the circular RNA decay machinery
Min Zhou1, Hui Shen2, Chuan Huang3
1Women and Children's Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), Chongqing 401147, China; Chongqing Municipal Health Commission Key Laboratory of Perinatal Medicine, Chongqing 401147, China; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Abstract:
Circular RNAs (circRNAs) are covalently closed, stable RNA molecules with broad physiological functions. Precise regulation of circRNA turnover is essential for cellular homeostasis. A recent study by Deng et al. uncovers an evolutionarily conserved mechanism in which RNAseK and the lysosome act synergistically to degrade circRNAs across metazoans.
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