Related Experiment Video

Updated: Aug 5, 2026

Isolation and Culture of Adult Mouse Cardiomyocytes for Cell Signaling and in vitro Cardiac Hypertrophy
06:51

Isolation and Culture of Adult Mouse Cardiomyocytes for Cell Signaling and in vitro Cardiac Hypertrophy

Published on: May 21, 2014

Let-7e-5p promotes cardiac hypertrophy by targeting LBH and regulating the IGF-PI3K-AKT signaling pathway

Shushu Yu1, Mingliang Wang2, Yun Xie2

  • 1School of Medicine, Tongji University, Shanghai, China.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|July 31, 2026
PubMed

Insights

Let-7e-5p, a microRNA, promotes cardiac hypertrophy by targeting LBH and activating the IGF-PI3K-AKT pathway. Inhibiting let-7e-5p may offer a novel therapeutic strategy for cardiac hypertrophy.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cardiology
  • Biochemistry

Background:

  • Cardiac hypertrophy is a heart response to stimuli, aiming to maintain function.
  • Let-7e-5p is found to be upregulated in cardiac hypertrophy patients.

Purpose of the Study:

  • Investigate the role of let-7e-5p in cardiac hypertrophy progression.
  • Explore let-7e-5p as a potential therapeutic target.

Main Methods:

  • Detected let-7e-5p expression in patient blood and animal models.
  • Utilized aortic banding and Angiotensin II to induce cardiac hypertrophy.
  • Employed antagomir let-7e-5p for gene silencing and investigated downstream targets.

Main Results:

  • Let-7e-5p was upregulated in hypertrophic cardiomyopathy patients and cardiac hypertrophy rat models.
  • Let-7e-5p deficiency alleviated cardiac hypertrophy.
  • Let-7e-5p targets LBH, influencing the IGF-PI3K-AKT pathway.

Conclusions:

  • Let-7e-5p promotes cardiac hypertrophy by targeting LBH and regulating the IGF-PI3K-AKT pathway.
  • This mechanism offers potential for novel targeted therapies in cardiac hypertrophy.
Abstract

Keywords:
IGF–PI3K–AKT signaling pathwayLBH proteinLet-7e-5pcardiac hypertrophymicroRNA regulation

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