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Coatings on Absorbable Meshes Used for Hernia Repair: A Scoping Review
Sophus Hvidt1, Jacob Rosenberg1, Jason Joe Baker1
1Department of Surgery, Center for Perioperative Optimization, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
Surgical Innovation
|July 31, 2026
Summary
Researchers reviewed 22 coatings for absorbable meshes in hernia repair. Mesenchymal stem cells and platelet-rich plasma showed promise in animal studies for improving outcomes and reducing recurrence, but clinical trials are needed.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Regenerative Medicine
Background:
- Permanent meshes for hernia repair have high recurrence rates and potential for chronic pain.
- Absorbable meshes reduce complications but risk increased hernia recurrence.
- Mesh coatings may enhance biocompatibility and surgical outcomes.
Purpose of the Study:
- To overview coatings applied to absorbable meshes for abdominal hernia repair.
- To report beneficial and adverse effects of these coated meshes.
Main Methods:
- Systematic review of studies on non-commercially coated absorbable meshes in abdominal hernia repair.
- Searched PubMed, Embase, Cochrane Central, LILACS, and CNKI without language constraints.
- Included human and animal studies; analysis focused on 46 included studies (all animal models).
Main Results:
- Twenty-two different coatings were identified, including mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP).
- MSCs and PRP enhanced cell ingrowth, collagen deposition, neovascularization, and tensile strength, while reducing inflammation.
- PRP showed variable anti-inflammatory effects but demonstrated promising preclinical results in reducing hernia recurrence.
Conclusions:
- Various coatings exist for absorbable meshes, yielding diverse results.
- MSCs and PRP were the most studied coatings in preclinical settings.
- PRP shows potential for reducing hernia recurrence, warranting further clinical investigation.
